Endocrine Abstracts

Thyroid hormones (TH), among their pleiotropic actions, play a central role in the regulation of metabolism and in cognitive functions. Indeed, hypothyroidism is associated with a decrease in energy expenditure and lipid metabolism, and an impairment of memory. Metabolic deregulations induced by a high fat diet (HFD) generate peripheral inflammation, which promotes the development of neuroinflammation in various brain regions. This inflammatory state can disrupt neuronal homeo...

Obesity rate keeps growing worldwide and weighs heavily on the healthcare system because of the related metabolic disorders like diabetes. In addition to calorie-rich diet and sedentary lifestyle, environmental exposure to obesogens, endocrine disrupting chemicals (EDC) targeting adipose tissue and its function as well as central pathways regulating food intake and energy expenditure, could add to the raising obesity incidence. The flame-retardant tetrabromobisphenol A (TBBPA)...